Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1637864	0.1003863	0.1176789
Weighted median	23	0.0812082	0.0574979	0.1578417
Inverse variance weighted	23	0.0437557	0.0392321	0.2647212
Simple mode	23	0.0713289	0.1043949	0.5015756
Weighted mode	23	0.0889389	0.0664591	0.1944831

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.12813	21	0.7033107
Inverse variance weighted	18.81552	22	0.6566911

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073705	0.005674	0.2080275

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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