Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1512335	0.1147926	0.2018817
Weighted median	23	0.0562246	0.0606922	0.3542436
Inverse variance weighted	23	0.0538698	0.0447083	0.2282346
Simple mode	23	0.1104207	0.1163328	0.3528408
Weighted mode	23	0.0717529	0.0887391	0.4274133

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46050	21	0.1561255
Inverse variance weighted	28.57079	22	0.1575276

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059787	0.0064883	0.3672792

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8