Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0416279	0.1149877	0.7209544
Weighted median	23	-0.0079185	0.0635484	0.9008356
Inverse variance weighted	23	0.0036235	0.0440964	0.9345101
Simple mode	23	0.0595865	0.1067209	0.5822512
Weighted mode	23	0.0248329	0.0795668	0.7579019

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.55408	21	0.153257
Inverse variance weighted	27.79391	22	0.182612

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027787	0.0064993	0.6733422

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008425	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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