Two sample MR report

Telomere_length against IDP dMRI TBSS L3 External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1499954	0.1332145	0.2728822
Weighted median	23	0.1469230	0.0598054	0.0140225
Inverse variance weighted	23	0.1741148	0.0509109	0.0006262
Simple mode	23	0.2830606	0.0884036	0.0041135
Weighted mode	23	0.1190064	0.0620452	0.0681750

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.98094	21	0.0169191
Inverse variance weighted	37.04907	22	0.0233642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014811	0.0075295	0.8459533

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001719	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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