Two sample MR report

Telomere_length against IDP dMRI TBSS L3 External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0962979	0.1306730	0.4693139
Weighted median	23	0.0703643	0.0570973	0.2178151
Inverse variance weighted	23	0.1485750	0.0501174	0.0030314
Simple mode	23	0.1233470	0.0882165	0.1759820
Weighted mode	23	0.0737422	0.0597599	0.2302325

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.58259	21	0.0243453
Inverse variance weighted	35.90266	22	0.0311035

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032101	0.0073858	0.6682679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015222	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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