Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3612339	0.1076032	0.0029836
Weighted median	23	0.2109128	0.0617646	0.0006383
Inverse variance weighted	23	0.1849436	0.0440761	0.0000272
Simple mode	23	0.1749509	0.1101491	0.1264855
Weighted mode	23	0.2029567	0.0840227	0.0244659

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.12992	21	0.2868061
Inverse variance weighted	27.77011	22	0.1834256

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108253	0.006082	0.0895702

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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