Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3022473	0.1244997	0.0242715
Weighted median	23	0.2163172	0.0595966	0.0002838
Inverse variance weighted	23	0.1686843	0.0490507	0.0005839
Simple mode	23	0.2195828	0.1135824	0.0661774
Weighted mode	23	0.2232124	0.0732794	0.0059259

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.30323	21	0.0545373
Inverse variance weighted	34.39273	22	0.0447867

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0082016	0.0070371	0.256889

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016022	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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