Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2582702	0.1262039	0.0534344
Weighted median	23	0.2001304	0.0585387	0.0006290
Inverse variance weighted	23	0.2196099	0.0483146	0.0000055
Simple mode	23	0.1991180	0.1061893	0.0741123
Weighted mode	23	0.2126037	0.0665534	0.0041861

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.19352	21	0.0441148
Inverse variance weighted	33.36858	22	0.0568739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002374	0.0071333	0.7425855

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019605	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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