Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1886783	0.1189178	0.1275407
Weighted median	23	0.2040929	0.0568064	0.0003272
Inverse variance weighted	23	0.2283699	0.0455477	0.0000005
Simple mode	23	0.2087002	0.0923849	0.0341310
Weighted mode	23	0.1931220	0.0667061	0.0083990

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.47083	21	0.1031488
Inverse variance weighted	29.65535	22	0.1270845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024373	0.0067215	0.720519

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019253	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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