Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3231387	0.1090748	0.0074305
Weighted median	23	0.1969747	0.0558186	0.0004174
Inverse variance weighted	23	0.2066376	0.0429618	0.0000015
Simple mode	23	0.2182572	0.0880049	0.0212724
Weighted mode	23	0.2030415	0.0587909	0.0022620

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.79400	21	0.2561963
Inverse variance weighted	26.38371	22	0.2355724

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071538	0.0061651	0.2589213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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