Two sample MR report

Telomere_length against IDP dMRI TBSS L3 Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2069781	0.1075002	0.0678323
Weighted median	23	0.1860463	0.0588022	0.0015565
Inverse variance weighted	23	0.2062626	0.0410464	0.0000005
Simple mode	23	0.1730156	0.0956023	0.0840197
Weighted mode	23	0.1488142	0.0582282	0.0180253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.08296	21	0.2890563
Inverse variance weighted	24.08302	22	0.3428927

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-4.39e-05	0.0060761	0.994299

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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