Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1264789	0.1078536	0.2540510
Weighted median	23	0.0983953	0.0577516	0.0884244
Inverse variance weighted	23	0.1826242	0.0414931	0.0000108
Simple mode	23	0.1157612	0.0956486	0.2390166
Weighted mode	23	0.1052741	0.0612675	0.0997915

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.24049	21	0.2815525
Inverse variance weighted	24.60969	22	0.3161013

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034476	0.0060961	0.577696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014022	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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