Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1172054	0.1545162	0.4565625
Weighted median	23	0.0681623	0.0615235	0.2679020
Inverse variance weighted	23	0.1541362	0.0639059	0.0158687
Simple mode	23	0.2291655	0.1216310	0.0728343
Weighted mode	23	0.0660197	0.0674728	0.3384830

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.75362	21	0.0003947
Inverse variance weighted	58.37681	22	0.0000387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0166616	0.0087334	0.0701862

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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