Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0601291	0.1179566	0.6155376
Weighted median	23	0.0677306	0.0586853	0.2484463
Inverse variance weighted	23	0.1137127	0.0452987	0.0120634
Simple mode	23	0.1028099	0.0975314	0.3032675
Weighted mode	23	0.0678850	0.0712959	0.3513617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.99406	21	0.1141442
Inverse variance weighted	29.33033	22	0.1356693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032903	0.0066671	0.6267722

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011433	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8