Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0173240	0.1201054	0.8866862
Weighted median	23	0.0580637	0.0559405	0.2992910
Inverse variance weighted	23	0.0933565	0.0463725	0.0440948
Simple mode	23	0.0404904	0.0905002	0.6589555
Weighted mode	23	0.0365743	0.0586344	0.5391937

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.06017	21	0.0907856
Inverse variance weighted	30.73722	22	0.1016193

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046688	0.0067885	0.4991412

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011029	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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