Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2044918	0.1412808	0.1625455
Weighted median	23	0.1789998	0.0589849	0.0024080
Inverse variance weighted	23	0.2351664	0.0540152	0.0000134
Simple mode	23	0.1170016	0.0864392	0.1896174
Weighted mode	23	0.1402739	0.0635138	0.0379263

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.59618	21	0.0047276
Inverse variance weighted	41.70638	22	0.0067827

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018836	0.0079854	0.8158141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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