Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0859628	0.1661984	0.6104008
Weighted median	23	0.0540658	0.0597687	0.3656860
Inverse variance weighted	23	0.1948706	0.0642187	0.0024095
Simple mode	23	0.0578081	0.0832832	0.4948752
Weighted mode	23	0.0670087	0.0567131	0.2500034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	57.56157	21	2.97e-05
Inverse variance weighted	58.95074	22	3.19e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066874	0.0093938	0.4843598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025334	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8