Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0960835	0.1120847	0.4009895
Weighted median	23	-0.0320843	0.0598807	0.5920941
Inverse variance weighted	23	-0.0059815	0.0435670	0.8907979
Simple mode	23	-0.0089037	0.1220713	0.9425144
Weighted mode	23	0.0001784	0.0911622	0.9984564

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.18000	21	0.1996686
Inverse variance weighted	27.13084	22	0.2062992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055328	0.0063353	0.392361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008228	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8