Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2589215	0.1090490	0.0271899
Weighted median	23	0.1342398	0.0619599	0.0302685
Inverse variance weighted	23	0.1349915	0.0431226	0.0017456
Simple mode	23	0.1089730	0.1165827	0.3600763
Weighted mode	23	0.1419349	0.0849317	0.1088551

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.78200	21	0.2567291
Inverse variance weighted	26.58091	22	0.2275778

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00761	0.0061637	0.2305969

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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