Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1011665	0.1003868	0.3250379
Weighted median	23	0.0664264	0.0570843	0.2445642
Inverse variance weighted	23	0.0339998	0.0392322	0.3861455
Simple mode	23	0.1103842	0.0931299	0.2485558
Weighted mode	23	0.0742874	0.0708610	0.3058574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.17835	21	0.5099909
Inverse variance weighted	20.70671	22	0.5389214

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041244	0.005674	0.4753204

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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