Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0643777	0.1011554	0.5313766
Weighted median	23	0.0594630	0.0584821	0.3092621
Inverse variance weighted	23	0.0351468	0.0392321	0.3703241
Simple mode	23	0.0804673	0.0992122	0.4260177
Weighted mode	23	0.0680537	0.0685115	0.3313554

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.32284	21	0.4393860
Inverse variance weighted	21.42291	22	0.4947496

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017949	0.0057175	0.7566656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006735	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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