Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0255411	0.1170881	0.8294293
Weighted median	23	0.0151260	0.0614354	0.8055196
Inverse variance weighted	23	0.0108736	0.0448292	0.8083499
Simple mode	23	0.0652356	0.1002300	0.5218782
Weighted mode	23	0.0360076	0.0761902	0.6411526

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.57007	21	0.1247117
Inverse variance weighted	28.72538	22	0.1528696

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002236	0.006618	0.7388128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008728	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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