Two sample MR report

Telomere_length against IDP dMRI TBSS L2 External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2048094	0.1231300	0.1110940
Weighted median	23	0.1308978	0.0543962	0.0161116
Inverse variance weighted	23	0.1551276	0.0472286	0.0010212
Simple mode	23	0.1931759	0.0888453	0.0407173
Weighted mode	23	0.1223093	0.0655300	0.0753632

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.59452	21	0.0643169
Inverse variance weighted	31.88361	22	0.0794020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030507	0.0069595	0.6656073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014394	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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