Two sample MR report

Telomere_length against IDP dMRI TBSS L2 External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1596302	0.1212227	0.2020847
Weighted median	23	0.0931061	0.0550233	0.0906229
Inverse variance weighted	23	0.1419705	0.0463132	0.0021735
Simple mode	23	0.0704441	0.0872905	0.4283012
Weighted mode	23	0.0737638	0.0578366	0.2154774

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.62245	21	0.0801751
Inverse variance weighted	30.65897	22	0.1033078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010844	0.0068517	0.8757594

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013256	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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