Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2973567	0.1161990	0.0182808
Weighted median	23	0.1615642	0.0648005	0.0126577
Inverse variance weighted	23	0.2017003	0.0452049	0.0000081
Simple mode	23	0.0713311	0.1219188	0.5644536
Weighted mode	23	0.0880268	0.0967194	0.3726207

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.13950	21	0.1362391
Inverse variance weighted	29.21127	22	0.1389272

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058739	0.0065679	0.381277

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016859	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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