Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3166385	0.1065605	0.0072813
Weighted median	23	0.1750550	0.0580620	0.0025701
Inverse variance weighted	23	0.1434920	0.0436023	0.0009986
Simple mode	23	0.1582595	0.1091853	0.1613160
Weighted mode	23	0.1987232	0.0692014	0.0088626

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.66455	21	0.3095944
Inverse variance weighted	27.17606	22	0.2046155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0106323	0.0060231	0.0920593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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