Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1129682	0.1150461	0.3373088
Weighted median	23	0.1689441	0.0590036	0.0041927
Inverse variance weighted	23	0.1758947	0.0442954	0.0000716
Simple mode	23	0.1750851	0.1085475	0.1210023
Weighted mode	23	0.1596565	0.0668660	0.0259728

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58241	21	0.1523968
Inverse variance weighted	28.04619	22	0.1741553

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003864	0.0065026	0.558709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014589	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8