Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2397353	0.1003844	0.0264044
Weighted median	23	0.1356055	0.0539434	0.0119422
Inverse variance weighted	23	0.1701349	0.0392314	0.0000145
Simple mode	23	0.1197756	0.0868955	0.1819415
Weighted mode	23	0.1386407	0.0634197	0.0397367

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.51934	21	0.7960203
Inverse variance weighted	16.08672	22	0.8115587

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042738	0.0056739	0.4596656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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