Two sample MR report

Telomere_length against IDP dMRI TBSS L2 Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0991616	0.1127302	0.3890116
Weighted median	23	0.1219942	0.0577362	0.0346044
Inverse variance weighted	23	0.1738624	0.0435710	0.0000660
Simple mode	23	0.1178957	0.1034305	0.2666053
Weighted mode	23	0.0982183	0.0730193	0.1922957

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.48263	21	0.1886408
Inverse variance weighted	27.13620	22	0.2060990

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004587	0.0063717	0.4795209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014173	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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