Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0689186	0.1003855	0.4998842
Weighted median	23	0.1338884	0.0548842	0.0147088
Inverse variance weighted	23	0.1267366	0.0392320	0.0012360
Simple mode	23	0.2088948	0.0890763	0.0284492
Weighted mode	23	0.1195415	0.0661735	0.0845418

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.72420	21	0.7276831
Inverse variance weighted	17.11573	22	0.7569422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035503	0.0056739	0.5382386

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008349	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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