Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1323459	0.1003852	0.2015756
Weighted median	23	0.1397365	0.0588134	0.0175049
Inverse variance weighted	23	0.1470830	0.0392317	0.0001775
Simple mode	23	0.1501533	0.1005249	0.1494605
Weighted mode	23	0.1446610	0.0714933	0.0553456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.15370	21	0.6392577
Inverse variance weighted	18.17914	22	0.6953157

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009049	0.005674	0.8748072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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