Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0704615	0.1003871	0.4904493
Weighted median	23	0.0467341	0.0567719	0.4103992
Inverse variance weighted	23	0.0625146	0.0392325	0.1110611
Simple mode	23	0.0964885	0.0933197	0.3123891
Weighted mode	23	0.0407114	0.0657110	0.5419164

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.04239	21	0.7672646
Inverse variance weighted	18.11335	22	0.6992468

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081654	0.005674	0.1648663

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006259	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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