Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0302578	0.1003874	0.7660663
Weighted median	23	0.0802162	0.0542319	0.1391047
Inverse variance weighted	23	0.0784224	0.0392325	0.0456175
Simple mode	23	0.1969737	0.0854506	0.0309717
Weighted mode	23	0.0523632	0.0636408	0.4194554

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.03161	21	0.9075128
Inverse variance weighted	13.30330	22	0.9243557

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029575	0.005674	0.6076523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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