Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3157051	0.1369390	0.0314416
Weighted median	23	0.1954251	0.0628885	0.0018869
Inverse variance weighted	23	0.2603448	0.0525257	0.0000007
Simple mode	23	0.1931951	0.1188769	0.1183678
Weighted mode	23	0.1931951	0.0736781	0.0155617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.08049	21	0.0096003
Inverse variance weighted	39.43946	22	0.0125610

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033994	0.0077401	0.6650041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8