Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1695613	0.1532094	0.2809281
Weighted median	23	0.1380944	0.0626224	0.0274407
Inverse variance weighted	23	0.2260468	0.0587213	0.0001184
Simple mode	23	0.0781699	0.1107149	0.4875693
Weighted mode	23	0.1191057	0.0675886	0.0919234

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.91731	21	0.0005150
Inverse variance weighted	49.29101	22	0.0007306

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034685	0.0086597	0.6928085

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024992	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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