Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2728708	0.1241654	0.0393305
Weighted median	23	0.0794153	0.0598462	0.1845121
Inverse variance weighted	23	0.0756037	0.0506615	0.1356129
Simple mode	23	0.1016524	0.1197918	0.4052562
Weighted mode	23	0.0940333	0.0794023	0.2489458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.12955	21	0.0568053
Inverse variance weighted	36.68756	22	0.0255917

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0121134	0.0070181	0.0990294

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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