Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1315633	0.1369262	0.3475691
Weighted median	23	0.0050121	0.0581604	0.9313261
Inverse variance weighted	23	-0.0264143	0.0542027	0.6260291
Simple mode	23	-0.1382781	0.1076115	0.2121653
Weighted mode	23	0.0174352	0.0708074	0.8077839

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.07075	21	0.0096261
Inverse variance weighted	41.99377	22	0.0062618

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097005	0.0077392	0.2238259

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012861	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8