Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0533099	0.1302485	0.6864689
Weighted median	23	-0.0224639	0.0559822	0.6882220
Inverse variance weighted	23	-0.0298203	0.0502984	0.5532694
Simple mode	23	-0.2093505	0.1057684	0.0604279
Weighted mode	23	0.0049148	0.0672353	0.9423877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.35226	21	0.0258210
Inverse variance weighted	36.16163	22	0.0291768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051045	0.0073617	0.4956648

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011131	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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