Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0493633	0.1212840	0.6881226
Weighted median	23	-0.0414799	0.0623890	0.5061402
Inverse variance weighted	23	-0.0351900	0.0463274	0.4474977
Simple mode	23	0.0049675	0.1143429	0.9657399
Weighted mode	23	0.0012899	0.0755355	0.9865290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.65428	21	0.0796073
Inverse variance weighted	30.67781	22	0.1028993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008703	0.0068552	0.9001822

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009539	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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