Two sample MR report

Telomere_length against IDP dMRI TBSS L1 External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1004508	0.1544637	0.5225375
Weighted median	23	0.0987642	0.0610267	0.1055814
Inverse variance weighted	23	0.0852212	0.0589936	0.1485747
Simple mode	23	0.0728349	0.1237741	0.5622231
Weighted mode	23	0.0640951	0.0770255	0.4142783

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.71956	21	0.0003990
Inverse variance weighted	49.74673	22	0.0006345

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009352	0.0087305	0.9157146

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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