Two sample MR report

Telomere_length against IDP dMRI TBSS L1 External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0479595	0.1594641	0.7665596
Weighted median	23	0.0272097	0.0617048	0.6592379
Inverse variance weighted	23	0.0644840	0.0609049	0.2897066
Simple mode	23	0.0515623	0.0960760	0.5968732
Weighted mode	23	0.0427864	0.0689618	0.5413453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.99041	21	0.0001380
Inverse variance weighted	53.02239	22	0.0002255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010147	0.0090131	0.9114339

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016883	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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