Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2054070	0.1165418	0.0925319
Weighted median	23	0.1645102	0.0562637	0.0034566
Inverse variance weighted	23	0.1778046	0.0445688	0.0000662
Simple mode	23	0.1432395	0.0974259	0.1556547
Weighted mode	23	0.1640881	0.0573571	0.0090853

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.30440	21	0.1317275
Inverse variance weighted	28.39363	22	0.1629999

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016949	0.0065871	0.799445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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