Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0361364	0.1245531	0.7745633
Weighted median	23	0.0732318	0.0560028	0.1909942
Inverse variance weighted	23	0.1066502	0.0479838	0.0262407
Simple mode	23	0.1148521	0.0999245	0.2627384
Weighted mode	23	0.0802134	0.0662183	0.2386139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.32808	21	0.0542193
Inverse variance weighted	32.91042	22	0.0631451

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043299	0.0070399	0.5451311

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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