Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1190247	0.1806595	0.5171614
Weighted median	23	0.0401361	0.0653342	0.5390045
Inverse variance weighted	23	0.0739206	0.0691006	0.2847300
Simple mode	23	0.0529482	0.1340114	0.6965721
Weighted mode	23	-0.0279077	0.0786276	0.7260184

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	68.01601	21	7.0e-07
Inverse variance weighted	68.25429	22	1.2e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027696	0.010211	0.7888592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021754	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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