Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0782739	0.1564793	0.6221227
Weighted median	23	0.0727096	0.0619784	0.2407380
Inverse variance weighted	23	0.1358246	0.0599737	0.0235290
Simple mode	23	0.1035433	0.1407525	0.4697202
Weighted mode	23	0.0594969	0.0680043	0.3910802

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.02560	21	0.0002622
Inverse variance weighted	51.41351	22	0.0003765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035339	0.0088443	0.6935149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001921	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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