Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1101389	0.1707378	0.5258634
Weighted median	23	-0.0000347	0.0593411	0.9995338
Inverse variance weighted	23	0.0352337	0.0655431	0.5908771
Simple mode	23	0.0581413	0.0955322	0.5490195
Weighted mode	23	0.0460131	0.0596892	0.4489793

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	60.74766	21	9.80e-06
Inverse variance weighted	61.40479	22	1.38e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045995	0.0096502	0.6385556

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018849	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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