Two sample MR report

Telomere_length against IDP dMRI TBSS L1 Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0110637	0.1479064	0.9410800
Weighted median	23	0.0247104	0.0558366	0.6580926
Inverse variance weighted	23	0.0246056	0.0564875	0.6631311
Simple mode	23	0.0268809	0.0887766	0.7648927
Weighted mode	23	0.0268809	0.0564841	0.6388366

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.58675	21	0.0014496
Inverse variance weighted	45.60822	22	0.0022202

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008315	0.0083598	0.9217105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013938	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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