Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0136806	0.1096189	0.9018678
Weighted median	23	0.0458234	0.0630951	0.4676800
Inverse variance weighted	23	0.0480385	0.0419708	0.2523872
Simple mode	23	0.0716141	0.1132966	0.5338397
Weighted mode	23	0.0656725	0.1092120	0.5537660

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.04012	21	0.2454307
Inverse variance weighted	25.17837	22	0.2886209

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021097	0.0061958	0.736854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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