Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0531448	0.1003890	0.6020879
Weighted median	23	0.0092349	0.0563239	0.8697624
Inverse variance weighted	23	-0.0101353	0.0392330	0.7961476
Simple mode	23	0.0062341	0.0911256	0.9460751
Weighted mode	23	0.0093537	0.0627342	0.8828330

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.79195	21	0.5984846
Inverse variance weighted	19.00859	22	0.6447982

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002641	0.0056741	0.6464039

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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