Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1901059	0.1003882	0.0721231
Weighted median	23	-0.0447694	0.0540222	0.4072615
Inverse variance weighted	23	-0.0001388	0.0392329	0.9971763
Simple mode	23	0.0261339	0.0966712	0.7894204
Weighted mode	23	-0.0463730	0.0634848	0.4728181

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.15859	21	0.7014487
Inverse variance weighted	21.38501	22	0.4970654

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0116649	0.0056741	0.0524429

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000648	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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